Introduction
Pet owners often seek effective solutions to manage their dogs’ anxiety, stress, or behavioral issues. Trazodone, a prescription medication commonly used in humans, is also frequently prescribed by veterinarians to help dogs with anxiety, phobias, and post-surgical recovery. If your vet has recommended 100mg of trazodone for your dog, you may have questions about its effectiveness, safety, and potential side effects. In this article, we’ll provide a comprehensive guide to 100mg of trazodone for dogs, covering its uses, proper dosage, possible risks, and key considerations to ensure your pet’s well-being.
What is Trazodone and How Does It Work?
Trazodone is an antidepressant medication classified as a serotonin antagonist and reuptake inhibitor (SARI). It works by increasing serotonin levels in the brain, which helps regulate mood and reduce anxiety. In veterinary medicine, trazodone is often used as an off-label treatment for anxiety-related conditions in dogs.
Common Uses of Trazodone for Dogs
- Separation Anxiety – Helps dogs cope with being left alone.
- Noise Phobia – Reduces stress caused by thunderstorms, fireworks, or loud noises.
- Veterinary Visits & Grooming Stress – Calms anxious pets before appointments.
- Post-Surgical Recovery – Prevents excessive activity and restlessness after surgery.
- Generalized Anxiety – Manages chronic stress and nervousness in dogs.
Is 100mg of Trazodone Safe for Dogs?
Recommended Dosage Guidelines
The appropriate trazodone dosage varies based on a dog’s weight, age, overall health, and specific condition. While 100mg may be suitable for some dogs, it is essential to follow your veterinarian’s prescription.
Typical Dosage Ranges:
- Small dogs (under 20 lbs) – 25mg to 50mg per dose
- Medium dogs (20-50 lbs) – 50mg to 100mg per dose
- Large dogs (over 50 lbs) – 100mg to 300mg per dose
Since every dog reacts differently, your vet may start with a lower dose and adjust based on your pet’s response.
Potential Side Effects of Trazodone in Dogs
Although trazodone is generally safe when administered correctly, some dogs may experience side effects. It’s crucial to monitor your dog and report any concerning symptoms to your veterinarian.
Common Side Effects:
- Lethargy or drowsiness
- Gastrointestinal issues (vomiting, diarrhea)
- Mild sedation
- Increased appetite
Serious Side Effects (Seek Immediate Vet Care):
- Excessive sedation or difficulty waking up
- Agitation or hyperactivity
- Uncoordinated movements (ataxia)
- Seizures
- Rapid breathing or heart rate changes
If you notice severe reactions, contact your vet immediately or visit an emergency animal hospital.
Can Dogs Overdose on Trazodone?
Yes, overdosing on trazodone can lead to severe complications, including dangerous drops in blood pressure, respiratory distress, tremors, and collapse. If you suspect an overdose, seek emergency veterinary care immediately.
Signs of a Trazodone Overdose in Dogs:
- Extreme lethargy or unconsciousness
- Vomiting and drooling
- Disorientation or confusion
- Tremors or seizures
How to Safely Administer Trazodone to Your Dog
To ensure maximum effectiveness and safety, follow these best practices when giving trazodone to your dog:
- Administer with food to reduce the risk of stomach upset.
- Give the correct dosage as prescribed by your vet.
- Monitor your dog’s behavior for any unusual reactions.
- Avoid combining trazodone with other sedatives without veterinary approval.
Alternatives to Trazodone for Anxiety in Dogs
If trazodone doesn’t work well for your dog or causes unwanted side effects, your vet may suggest alternative treatments such as:
- Natural calming supplements (CBD oil, melatonin, L-theanine)
- Behavioral training and desensitization techniques
- Other prescription medications (fluoxetine, alprazolam)
Conclusion
100mg of trazodone can be a safe and effective treatment for anxiety and stress in dogs when used under veterinary supervision. While it offers numerous benefits, it’s important to administer the medication correctly and be aware of potential side effects. Always consult your veterinarian before starting any new medication for your dog.
If you have concerns about your dog’s anxiety or trazodone dosage, schedule a consultation with your vet today to discuss the best treatment options. Your pet’s well-being is the top priority, and with the right approach, you can help them lead a calmer, happier life!

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.