Is your dog struggling with anxiety, restlessness, or post-surgery recovery? If so, your vet might have mentioned trazodone—a commonly prescribed medication for canine anxiety and behavioral issues. But when it comes to dosage, especially 100mg tablets, pet owners often have questions.
How much is too much? What’s safe for small vs. large breeds? In this guide, we’ll break down everything you need to know with a clear dosage chart, safety tips, and answers to common concerns about trazodone for dogs.
What Is Trazodone and Why Is It Used in Dogs?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that was originally developed to treat depression in humans. However, it’s now frequently used in veterinary medicine to help dogs with:
- Anxiety (separation, noise phobia, travel-related)
- Post-operative calming
- Behavioral modification training
- Aggression management
It works by balancing serotonin levels in the brain, promoting relaxation and reducing anxious behaviors.
Is 100mg of Trazodone Safe for Dogs?
Yes—but only under veterinary supervision. The appropriate dose depends on your dog’s:
- Weight
- Overall health
- Age
- Other medications they may be taking
Trazodone is generally well-tolerated, but giving the wrong dosage can cause side effects or be ineffective. Always consult your vet before giving this medication.
100mg Trazodone Dosage Chart for Dogs
Below is a general trazodone dosage chart based on body weight. The typical dosage range is 2.5–7 mg per pound (5–15 mg/kg) every 8–24 hours.
| Dog’s Weight | Low Dose (2.5 mg/lb) | Moderate Dose (5 mg/lb) | High Dose (7 mg/lb) |
|---|---|---|---|
| 10 lbs | 25 mg | 50 mg | 70 mg |
| 20 lbs | 50 mg | 100 mg | 140 mg |
| 30 lbs | 75 mg | 150 mg | 210 mg |
| 50 lbs | 125 mg | 250 mg | 350 mg |
| 70 lbs | 175 mg | 350 mg | 490 mg |
| 100 lbs | 250 mg | 500 mg | 700 mg |
⚠️ Important: This chart is a general guide. Your vet may adjust the dose based on your dog’s needs. Trazodone can be given once or twice daily, depending on the treatment goal.
How to Administer 100mg Trazodone Tablets to Your Dog
If your vet prescribes a 100mg tablet, here are a few tips:
- Split the tablet if your dog’s dose is below 100mg.
- Use pill pockets or wrap the tablet in a treat.
- Give with food to reduce the risk of stomach upset.
- Watch your dog for side effects (more on this below).
Common Side Effects of Trazodone in Dogs
Trazodone is usually safe, but some dogs may experience mild to moderate side effects, especially when starting the medication or receiving a higher dose.
Watch for:
- Lethargy or sedation
- Vomiting or diarrhea
- Panting or restlessness
- Dilated pupils
- Incoordination
- Agitation (rare)
🐾 If any of these symptoms appear severe or persist, contact your veterinarian immediately.
When Should Trazodone Be Avoided?
Trazodone might not be suitable if your dog:
- Is pregnant or nursing
- Has heart, liver, or kidney disease
- Is already taking other serotonergic drugs (risk of serotonin syndrome)
- Has had an adverse reaction to antidepressants
Your vet will assess these risks and recommend safe alternatives if needed.
Tips for Using Trazodone Effectively
To get the most benefit from trazodone while minimizing risks:
- Follow dosage instructions carefully
- Don’t abruptly stop the medication
- Allow 1–2 hours for the medication to take effect
- Use in combination with behavioral training for long-term improvement
- Store the medication out of reach of pets and children
Alternatives to Trazodone for Dogs
If your dog doesn’t tolerate trazodone well or needs something else, alternatives include:
- Gabapentin – another calming medication
- Clonidine – often used for noise phobias
- CBD oil – holistic option (discuss with your vet first)
- Behavioral therapy – long-term management tool
Final Thoughts: Is 100mg Trazodone Right for Your Dog?
Trazodone can be a lifesaver for anxious or recovering dogs, helping them stay calm and comfortable. However, dosage accuracy is key—and the 100mg tablet isn’t a one-size-fits-all solution.
Always work with your vet to determine the best dose, especially when using higher strengths like 100mg. Whether it’s a single tablet or a split dose, your vet’s guidance ensures your pup stays safe and relaxed.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.