Trazodone is a medication that’s been around for decades, originally developed to treat depression, but now widely prescribed for insomnia, anxiety, and even chronic pain. One of the most common dosages is 100mg, but how does that fit into the broader treatment landscape?
Whether you’ve just been prescribed trazodone or you’re researching it for a loved one, understanding how the 100mg dosage works—along with how it compares to other dosages—is key to safe and effective use.
In this guide, we’ll break it down with an easy-to-follow trazodone dosage chart, discuss how it’s used, and what to expect at the 100mg level.
What Is Trazodone?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It increases serotonin levels in the brain, which helps regulate mood and sleep.
It’s primarily prescribed for:
- Major depressive disorder (MDD)
- Insomnia
- Generalized anxiety disorder (GAD)
- Chronic pain (off-label)
Because it’s sedating at low doses and activating at higher ones, dosage plays a crucial role in how trazodone works in the body.
Trazodone Dosage Overview
Trazodone is available in several dosage strengths, usually ranging from 25mg to 300mg per dose, with some patients going up to 600mg per day under medical supervision.
Here’s a quick glance at the typical dosage ranges:
| Dosage | Common Use | Frequency |
|---|---|---|
| 25mg–50mg | Insomnia, mild anxiety | Once daily at bedtime |
| 100mg | Moderate insomnia, depression | Once or twice daily |
| 150mg–300mg | Major depression, chronic pain | Divided doses throughout day |
| 400mg–600mg | Severe depression (rare cases) | Supervised, divided doses |
Understanding the 100mg Trazodone Dosage
Is 100mg a High Dose?
Not necessarily. 100mg is considered a moderate dose, commonly used for:
- Treating moderate depression
- Managing sleep disorders (when lower doses don’t work)
- Providing daytime anxiety relief in split doses
It’s often the starting point for people who didn’t respond to 50mg, especially if insomnia is severe or accompanied by depressive symptoms.
When Is 100mg Prescribed?
A doctor might prescribe 100mg when:
- Lower doses fail to improve symptoms
- Patient needs a dual effect (sleep + mood improvement)
- There’s resistance to other antidepressants
- It’s part of a multi-drug treatment plan
How to Take 100mg Trazodone
Always follow your doctor’s instructions, but here’s how the 100mg dose is typically administered:
Single Dose at Bedtime
- Ideal for insomnia or sleep disturbances
- Helps induce sleep without a next-day hangover feeling (for most people)
Split Doses (50mg Twice a Day)
- Common for daytime anxiety or depression
- Reduces sedation during the day
- Allows for more balanced symptom control
Pro Tip: Trazodone should be taken with food to improve absorption and reduce stomach upset.
What to Expect from 100mg Trazodone
Here’s a breakdown of how trazodone at 100mg may affect you:
Positive Effects
- Improved sleep quality
- Reduced anxiety or depressive symptoms
- Decreased nighttime waking
- Fewer early morning awakenings
Potential Side Effects
Like all medications, trazodone can cause side effects. Common ones at 100mg include:
- Drowsiness (especially in the first few days)
- Dry mouth
- Dizziness
- Headache
- Nausea
Less common but serious side effects can include:
- Low blood pressure (hypotension)
- Priapism (painful, prolonged erection)
- Heart rhythm issues (arrhythmia)
If you experience any severe reactions, seek medical attention immediately.
Who Should Avoid 100mg Trazodone?
Trazodone isn’t for everyone. Be cautious if you:
- Have heart issues or a history of arrhythmia
- Take other medications that affect serotonin levels
- Are prone to hypotension
- Are pregnant or breastfeeding (consult your doctor)
Tips for Safe Use
To make sure you get the most out of your medication:
- Start low, go slow: Let your body adjust to new dosages
- Don’t mix with alcohol or sedatives unless approved
- Don’t stop abruptly – taper down under medical supervision
- Keep it consistent – take it at the same time every day
When to Talk to Your Doctor
If you’re currently on 100mg of trazodone or considering it, speak to your healthcare provider if:
- Symptoms persist or worsen
- You experience daytime drowsiness or difficulty concentrating
- You’re having side effects that affect your quality of life
- You’re planning to start or stop other medications
Your dosage may need to be adjusted or fine-tuned over time.
Final Thoughts: Is 100mg Trazodone Right for You?
The 100mg dosage of trazodone sits at a sweet spot for many patients—strong enough to relieve symptoms but still considered safe for long-term use under supervision.
As always, individual response varies, so finding the right dosage often takes some patience and open communication with your doctor.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.