Is your dog struggling with anxiety, stress, or sleepless nights? If so, you’re not alone. Many pet parents are turning to medications like Trazodone to help their furry friends feel calm and relaxed. Originally developed as an antidepressant for humans, Trazodone is commonly prescribed by vets for dogs, especially for anxiety, behavioral issues, and post-surgery recovery.
But how much is safe? And what does a 100mg Trazodone tablet mean for your dog’s weight? In this guide, we’ll break it all down—from how it works to a detailed dosage chart by weight—so you can feel confident about your pup’s care.
What Is Trazodone and Why Is It Used for Dogs?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It helps balance serotonin levels in the brain, promoting a sense of calm. Vets often prescribe it for:
- Generalized anxiety
- Noise phobias (like thunderstorms or fireworks)
- Separation anxiety
- Post-operative restlessness
- Travel stress
Unlike some sedatives, Trazodone doesn’t knock dogs out completely, making it a popular choice for short-term and long-term use.
Is 100mg Trazodone Safe for Dogs?
The answer depends on your dog’s weight, age, health, and tolerance to the drug. While 100mg is a common strength available at pharmacies, the safe dose varies widely between small and large breeds.
Veterinarians typically prescribe 1.7 mg to 6.8 mg of Trazodone per pound of body weight, administered every 8 to 24 hours, depending on the dog’s needs and response.
💡 Always consult your veterinarian before starting Trazodone. Self-medicating can lead to overdose or ineffective treatment.
Trazodone Dosage Chart for Dogs by Weight
Here’s a general dosage chart based on typical vet-prescribed ranges. The exact dosage should be customized by a vet, but this can give you a rough idea of what to expect with a 100mg Trazodone tablet.
Note: Doses are rounded and for informational purposes only. Always follow your vet’s instructions.
| Dog Weight (lbs) | Low Dose (mg) | Moderate Dose (mg) | Approximate 100mg Tablet Usage |
|---|---|---|---|
| 5 lbs | 8.5 mg | 25 mg | 1/8 to 1/4 tablet |
| 10 lbs | 17 mg | 50 mg | 1/4 to 1/2 tablet |
| 20 lbs | 34 mg | 100 mg | 1/2 to 1 tablet |
| 30 lbs | 51 mg | 150 mg | 1/2 to 1.5 tablets |
| 50 lbs | 85 mg | 250 mg | 1 to 2.5 tablets |
| 70 lbs | 119 mg | 340 mg | 1 to 3.5 tablets |
| 90 lbs | 153 mg | 425 mg | 1.5 to 4.25 tablets |
🔹 Tip: Trazodone can be compounded into flavored liquids or chewables for easier dosing, especially for smaller dogs.
How Long Does Trazodone Take to Work in Dogs?
Trazodone typically begins to take effect within 30 to 60 minutes after administration. Peak effects occur at around 2 hours and can last anywhere from 4 to 12 hours, depending on the dog’s metabolism and dose.
Common Use Scenarios:
- One-time dose before a stressful event (vet visit, fireworks)
- Daily use for chronic anxiety or post-operative care
- Short-term use during transitions (new home, travel)
Side Effects of Trazodone in Dogs
Most dogs tolerate Trazodone well, but as with any medication, side effects can occur.
Common side effects:
- Drowsiness or lethargy
- GI upset (vomiting, diarrhea)
- Panting
- Agitation or restlessness
- Uncoordinated movements
Rare but serious effects:
- Serotonin syndrome (when combined with other medications)
- Low blood pressure
- Seizures (very rare)
🚨 Call your vet immediately if your dog shows signs of distress, extreme sedation, or unusual behavior after taking Trazodone.
When to Avoid Trazodone for Dogs
Trazodone may not be suitable for all dogs. Avoid or use with caution if your dog has:
- Liver or kidney disease
- Heart conditions
- Is on MAO inhibitors or SSRIs
- Is pregnant or nursing
Always give your vet a full medical history before starting treatment.
Tips for Administering 100mg Trazodone Safely
Giving medication to pets can be tricky! Here are some quick tips:
- Use a pill cutter to break tablets into precise doses
- Mix with a small amount of food or a treat to mask the taste
- Keep a log of when and how much you’re giving
- Watch for side effects and report anything unusual to your vet
Final Thoughts: Talk to Your Vet Before You Dose
Trazodone can be a game-changer for anxious or restless dogs, but it’s not one-size-fits-all. While 100mg tablets are commonly prescribed, the actual dosage should always match your dog’s weight and needs.
📞 Your next step? Talk to your vet. Ask them about Trazodone if your dog shows signs of anxiety, stress, or behavioral changes. With the right plan, your pup can be calmer, safer, and more at ease.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.