Is your dog dealing with anxiety, stress, or sleep issues? If so, your vet may have prescribed trazodone—a human antidepressant increasingly used in veterinary medicine. But understanding the right trazodone dosage for dogs, especially the 100mg tablet, can feel overwhelming.
This article breaks it all down. We’ll cover what trazodone is, why it’s prescribed for dogs, how to dose it safely based on your dog’s weight, and what side effects to watch out for. Let’s get into it!
What Is Trazodone and Why Is It Used for Dogs?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) commonly used in people to treat depression and anxiety. In dogs, it’s prescribed off-label to manage:
- Anxiety and phobias (e.g., thunder, fireworks, car rides)
- Separation anxiety
- Post-surgical confinement stress
- Aggression linked to fear or stress
- Sleep disorders
It works by balancing serotonin levels in the brain, promoting calmness without heavy sedation. Most vets consider it safe and effective, especially for short-term use or as part of a behavior modification plan.
Is 100mg Trazodone Safe for Dogs?
Yes—100mg trazodone tablets are commonly prescribed for medium to large dogs. However, the correct dosage depends entirely on your dog’s weight and overall health.
Never give trazodone without veterinary guidance. The wrong dose can be ineffective or even harmful.
Trazodone Dosage Chart by Weight (Using 100mg Tablets)
Below is a general trazodone dosage chart for dogs, using the standard guideline of 2.5–7 mg per pound (5–15 mg/kg) every 8 to 24 hours. Always start at the low end and adjust under vet supervision.
💊 Trazodone Dosage Chart (Approximate Guidelines)
| Dog Weight (lbs) | Low Dose (mg) | High Dose (mg) | 100mg Tablet Equivalent |
|---|---|---|---|
| 10 lbs | 25 mg | 70 mg | ¼ to ¾ tablet |
| 20 lbs | 50 mg | 140 mg | ½ to 1.5 tablets |
| 30 lbs | 75 mg | 210 mg | ¾ to 2 tablets |
| 40 lbs | 100 mg | 280 mg | 1 to 2.75 tablets |
| 50 lbs | 125 mg | 350 mg | 1.25 to 3.5 tablets |
| 60 lbs | 150 mg | 420 mg | 1.5 to 4 tablets |
| 70 lbs | 175 mg | 490 mg | 1.75 to 5 tablets |
| 80 lbs | 200 mg | 560 mg | 2 to 5.5 tablets |
| 90 lbs | 225 mg | 630 mg | 2.25 to 6.25 tablets |
| 100 lbs | 250 mg | 700 mg | 2.5 to 7 tablets |
🐶 Note: Start with the lowest effective dose and observe your dog’s reaction. Your vet may recommend a gradual increase if needed.
How to Give Trazodone to Your Dog
Here are a few tips for giving trazodone safely:
- Give with food to reduce stomach upset.
- Use a pill pocket or wrap it in cheese for easy administration.
- Administer 1–2 hours before a stressful event for best results.
- If prescribed long-term, give it at the same time each day.
Possible Side Effects of Trazodone in Dogs
Most dogs tolerate trazodone well, especially when dosed correctly. However, side effects can occur—especially at higher doses.
🧠 Common Side Effects:
- Sedation or drowsiness
- Lethargy
- Gastrointestinal upset (vomiting, diarrhea)
- Hyperactivity or restlessness (paradoxical effect)
⚠️ Serious Side Effects (Rare):
- Serotonin syndrome (tremors, agitation, rapid heart rate)
- Disorientation or unsteady gait
- Aggression or unusual behavior
🚨 If you notice severe reactions, contact your vet or an emergency animal hospital right away.
When to Avoid Trazodone for Dogs
Trazodone may not be suitable for all dogs. Tell your vet if your dog:
- Has liver or kidney disease
- Is on MAOIs or other serotonergic drugs
- Has a history of seizures
- Is pregnant or nursing
It’s also important to inform your vet about any other medications your dog is taking to avoid dangerous interactions.
Alternatives to Trazodone
If trazodone isn’t a good fit, your vet might recommend:
- Gabapentin – Another sedative/anxiolytic often combined with trazodone
- Fluoxetine (Prozac) – For long-term anxiety management
- CBD oil – Natural, but research is still limited
- Behavior modification training – Often used with medication for lasting results
Final Thoughts: Is 100mg Trazodone Right for Your Dog?
Trazodone can be a game-changer for dogs struggling with anxiety, stress, or surgery recovery—but only when used correctly. The 100mg tablet is a convenient size, especially for medium and large breeds, but always dose by weight and vet guidance.
Understanding how trazodone works, how much to give, and what to watch out for helps you support your pup’s health and well-being with confidence.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.