Is your dog struggling with anxiety, stress, or trouble sleeping? If so, you might have come across Trazodone as a possible solution. This human antidepressant is commonly prescribed by veterinarians to help dogs cope with anxiety, post-surgical discomfort, or behavior-related issues. But figuring out the right dosage—especially with 100mg Trazodone tablets—can be confusing for pet owners.
This guide will break down everything you need to know, including a 100mg Trazodone dosage chart, how to calculate the proper dose for your pup, potential side effects, and important safety tips. Whether you’re new to Trazodone or just need a quick reference, this article has you covered.
What Is Trazodone and Why Is It Used for Dogs?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that’s used in veterinary medicine to manage:
- Generalized anxiety
- Noise phobia (e.g., fireworks, thunderstorms)
- Travel anxiety
- Separation anxiety
- Post-operative sedation
It works by increasing serotonin levels in the brain, promoting calmness and reducing nervous behavior.
Although originally developed for humans, Trazodone is considered safe and effective for dogs when used under veterinary guidance.
How Trazodone Is Administered to Dogs
Trazodone is typically given orally in tablet form, and 100mg is one of the more common dosages available. However, the appropriate dose is based on your dog’s weight, age, medical history, and reason for treatment.
Dogs usually receive 1.7 to 19.5 mg per kilogram (0.8 to 9 mg per pound), and it may be administered once or twice daily depending on the veterinarian’s recommendation.
100mg Trazodone for Dogs: Dosage Chart by Weight
Here’s a general dosage chart using 100mg tablets as a reference. Keep in mind, this is for educational purposes only—you should always follow your vet’s advice.
| Dog Weight (lbs) | Low Dose (mg) | Moderate Dose (mg) | High Dose (mg) | 100mg Tablet Equivalent |
|---|---|---|---|---|
| 10 lbs | 8 mg | 45 mg | 90 mg | ⅛ – 1 tablet |
| 20 lbs | 16 mg | 90 mg | 180 mg | ⅕ – 2 tablets |
| 30 lbs | 24 mg | 135 mg | 270 mg | ¼ – 2.5 tablets |
| 50 lbs | 40 mg | 225 mg | 450 mg | ½ – 4.5 tablets |
| 70 lbs | 56 mg | 315 mg | 630 mg | ¾ – 6 tablets |
| 90 lbs | 72 mg | 405 mg | 810 mg | 1 – 8 tablets |
Note: If you’re using 100mg tablets, you may need to cut or split the pills to reach the correct dosage.
How to Calculate the Right Trazodone Dose for Your Dog
To calculate Trazodone dosage, follow this formula:
Dog’s weight (lbs) × dosage (mg/lb) = total dose in mg
Example:
- Dog weight = 30 lbs
- Recommended dose = 3 mg/lb
- 30 × 3 = 90 mg total dose
If you have 100mg tablets, you could give just under one full tablet or consult your vet about using a pill splitter.
For added convenience, many pet parents use a Trazodone dosage calculator, which automatically estimates the correct dose based on weight and condition. Look for vet-approved calculators online or ask your vet to recommend one.
Important Safety Tips
While Trazodone is generally safe, it’s vital to use it only under veterinary supervision. Here are some important precautions:
- Do not give Trazodone with MAO inhibitors or certain antidepressants unless instructed.
- Monitor your dog after the first dose for any unusual reactions.
- Start with the lowest effective dose and adjust gradually if needed.
- Avoid giving it with food containing tryptophan, which can increase serotonin levels excessively.
Potential Side Effects of Trazodone in Dogs
Most dogs tolerate Trazodone well, but side effects can occur, especially with improper dosing or drug interactions. Common side effects include:
- Lethargy or sedation
- Gastrointestinal upset (vomiting or diarrhea)
- Panting or restlessness
- Incoordination
- Behavioral changes
In rare cases, dogs can experience serotonin syndrome, a potentially life-threatening condition. Symptoms include:
- Tremors
- Seizures
- Hyperthermia
- Rapid heart rate
If you notice any of these signs, seek emergency veterinary care immediately.
Can You Give 100mg Trazodone to Small Dogs?
Yes, but with caution. Since 100mg may be too strong for small dogs, you’ll likely need to split the tablet or opt for a lower-dose formulation. Dogs under 20 lbs typically require 25–75 mg per dose, depending on their condition.
Always double-check with your vet before administering any medication to small or toy breeds.
When Will Trazodone Start Working?
Trazodone usually takes 1 to 2 hours to take effect and can last between 6 to 12 hours, depending on the dog’s metabolism and the dosage. For situational anxiety (like fireworks), give the dose 1–2 hours before the event.
For chronic anxiety or behavioral treatment, it may take a few days of consistent use to see full results.
Final Thoughts: Trazodone Can Be a Safe, Effective Option
Trazodone can be a game-changer for anxious or recovering dogs—as long as it’s used responsibly. With a solid understanding of how to dose 100mg tablets and access to a clear dosage chart or calculator, you can help your pup feel calm and comfortable.
Always consult with your veterinarian before starting or changing any medication. They’ll help determine the best dosage, monitor for side effects, and guide you on long-term use if needed.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.