When your dog is anxious, recovering from surgery, or struggling with behavioral issues, it’s tough to watch them suffer. That’s where Trazodone—a commonly prescribed medication in veterinary care—often comes into play. But understanding the right dosage is crucial, especially if you’re using 100mg Trazodone tablets.
In this guide, we’ll walk you through how Trazodone works, when it’s prescribed, and—most importantly—how to calculate the proper dosage by your dog’s weight using a helpful Trazodone dosage chart.
What Is Trazodone and Why Is It Used for Dogs?
Trazodone is an antidepressant and sedative originally designed for humans, but it’s become widely used in veterinary medicine due to its calming effects on dogs.
Common Uses for Trazodone in Dogs
- Anxiety (separation, travel, thunderstorms)
- Post-surgical calming
- Behavioral modification training
- Veterinary visit stress
Trazodone works by altering serotonin levels in the brain, helping dogs feel more relaxed without heavy sedation.
Is 100mg Trazodone Safe for Dogs?
The 100mg tablet is a common size prescribed to medium or large dogs, but whether it’s appropriate for your pup depends entirely on their weight and health status. Smaller dogs usually require a lower dose, often starting at 25mg or 50mg.
👉 Never administer Trazodone without consulting your veterinarian. Overdosing can lead to serious side effects.
Trazodone Dosage Guidelines by Weight
Dosage typically falls between 2.5 to 7 mg per pound of body weight, given every 8 to 24 hours, depending on the dog’s needs.
💊 General Trazodone Dosage Formula:
Dog’s weight (lbs) × 3 mg = Average starting dose
Below is a helpful Trazodone dosage chart for dogs using the 100mg tablet as a reference point.
📊 Trazodone Dosage Chart by Dog Weight (Based on 3 mg/lb)
| Dog Weight (lbs) | Approximate Dose (mg) | 100mg Tablet Usage |
|---|---|---|
| 10 lbs | 30 mg | 1/3 tablet |
| 20 lbs | 60 mg | 2/3 tablet |
| 30 lbs | 90 mg | Almost 1 tablet |
| 40 lbs | 120 mg | 1.25 tablets |
| 50 lbs | 150 mg | 1.5 tablets |
| 60 lbs | 180 mg | 1.75 tablets |
| 70 lbs | 210 mg | 2 tablets + |
| 80+ lbs | 240+ mg | 2.5+ tablets |
Note: This chart is for general reference only. Always use your vet’s exact prescription.
Using a Trazodone Dosage Calculator
If you prefer quick calculations without charts, you can use this simple formula or online Trazodone dosage calculators:
Formula:Your dog’s weight (lbs) × mg per lb (e.g., 3) = Total mg needed
Example:
If your dog weighs 25 lbs and your vet recommends 3 mg/lb:
→ 25 × 3 = 75 mg
→ You’d give ¾ of a 100mg tablet.
Online calculators may allow you to select weight, dosage range, and tablet strength for fast results—just be sure the source is reputable.
How to Administer Trazodone to Dogs
Some dogs will swallow tablets easily; others need a bit of trickery.
Tips for Giving Trazodone:
- Hide in peanut butter or cheese
- Use pill pockets designed for dogs
- Crush and mix with food (only if your vet says it’s okay)
- Give with food to reduce risk of nausea
Be consistent with timing and dosage for best results.
Possible Side Effects of Trazodone in Dogs
Trazodone is generally safe, but some dogs may experience side effects—especially at higher doses or when used with other medications.
⚠️ Common Side Effects:
- Lethargy or drowsiness
- Gastrointestinal upset (vomiting, diarrhea)
- Agitation or restlessness
- Disorientation
Severe symptoms like collapse, seizures, or serotonin syndrome (rare) require emergency care.
Always monitor your dog after the first few doses and report any concerns to your vet.
Frequently Asked Questions (FAQs)
How long does it take for Trazodone to work in dogs?
Trazodone typically starts working within 30–60 minutes after oral administration.
How long does Trazodone last in dogs?
The effects usually last 4 to 8 hours, depending on dosage and your dog’s metabolism.
Can I give Trazodone daily?
Yes, but only under your vet’s guidance. Long-term use should be monitored for side effects or interactions with other medications.
Final Thoughts: Know the Right Dose, Keep Your Dog Safe
Trazodone can be a lifesaver for anxious or post-op pups, but dosage matters. Whether you’re using a 100mg tablet or a different strength, the key is tailoring the amount to your dog’s exact weight and needs.
When in doubt:
- Consult your veterinarian
- Use a dosage chart or calculator
- Start with the lowest effective dose
Your dog’s safety and comfort are worth every bit of care and attention.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.