When your dog is anxious, fearful, or recovering from surgery, finding a safe and effective way to help them relax is essential. Trazodone, a commonly prescribed human antidepressant, is increasingly used by veterinarians to treat canine anxiety, stress, and behavioral issues. But how much is safe for your furry friend? This article will walk you through everything you need to know about 100mg trazodone for dogs, provide a clear dosage chart, and offer a free downloadable PDF tailored for dog owners in the USA.
What Is Trazodone and Why Is It Prescribed for Dogs?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI), originally developed to treat depression and anxiety in humans. In veterinary medicine, it’s often used for:
- Separation anxiety
- Noise phobia (e.g., fireworks, thunderstorms)
- Post-operative calming
- Travel-related stress
- Veterinary visits or grooming anxiety
How It Works
Trazodone boosts serotonin levels in the brain, which helps promote a sense of calm and relaxation. It’s non-addictive, has mild sedative properties, and is generally well-tolerated by dogs.
100mg Trazodone for Dogs: Is It Safe?
100mg tablets of trazodone are often prescribed for medium to large dogs, but the actual dosage depends on your dog’s weight, age, health status, and specific condition. Giving the wrong amount can lead to side effects such as lethargy, gastrointestinal upset, or in rare cases, serotonin syndrome.
✅ Always consult your veterinarian before starting your dog on trazodone or adjusting the dose.
Trazodone Dosage Guidelines for Dogs
Here’s a general guideline based on mg per pound (or mg per kg). Most vets recommend 1.5 to 5 mg per pound, given every 8 to 24 hours depending on the situation.
💊 Trazodone Dosage Chart for Dogs (100mg Tablet)
Dog Weight (lbs) | Low Dose (1.5 mg/lb) | Medium Dose (3 mg/lb) | High Dose (5 mg/lb) |
---|---|---|---|
10 lbs | 15 mg | 30 mg | 50 mg |
20 lbs | 30 mg | 60 mg | 100 mg |
30 lbs | 45 mg | 90 mg | 150 mg |
40 lbs | 60 mg | 120 mg | 200 mg |
50 lbs | 75 mg | 150 mg | 250 mg |
60 lbs | 90 mg | 180 mg | 300 mg |
70 lbs | 105 mg | 210 mg | 350 mg |
80 lbs | 120 mg | 240 mg | 400 mg |
📌 Note: This chart is for educational purposes only. Doses may be split or adjusted based on your dog’s response and vet’s instructions.
Downloadable Trazodone Dosage Chart PDF (USA)
To make dosing easier, we’ve created a printable PDF version of the trazodone dosage chart tailored for U.S. pet owners.
🔽 Click here to download the Trazodone for Dogs Dosage Chart (PDF)
This chart includes:
- Dog weight categories
- Low, medium, and high dose ranges
- Space for vet notes
- Emergency contact info section
Keep a copy in your dog’s medical file or on your fridge for quick reference.
Tips for Administering Trazodone to Your Dog
Getting your dog to take medication doesn’t have to be a struggle. Here are some helpful tips:
- Use a pill pocket or soft treat to hide the tablet.
- Crush and mix with wet food (if approved by your vet).
- Give it 30 to 90 minutes before a stressful event (like a vet visit or car ride).
- Watch for side effects like vomiting, sedation, or restlessness.
🐾 Pro Tip: If your dog is on other medications, ask your vet about possible interactions with trazodone.
Potential Side Effects and Warnings
Trazodone is generally safe when used properly, but side effects can happen, especially at higher doses.
Common Side Effects
- Drowsiness
- Lethargy
- GI upset (vomiting or diarrhea)
- Panting or drooling
Serious Reactions (Seek Vet Care Immediately)
- Hyperactivity or agitation
- Tremors or seizures
- Serotonin syndrome (rare, but dangerous)
If any concerning symptoms occur, contact your veterinarian immediately or call the ASPCA Animal Poison Control Center at (888) 426-4435.
Frequently Asked Questions (FAQs)
❓ Can I cut a 100mg trazodone tablet for my dog?
Yes, if your vet instructs it. Trazodone tablets can be split into halves or quarters using a pill cutter for smaller doses.
❓ How long does trazodone last in dogs?
Effects usually kick in within 30–90 minutes and last 6–12 hours, depending on your dog’s metabolism and dose.
❓ Is trazodone safe for long-term use?
Many dogs take trazodone safely for weeks or months, but long-term use should be monitored by your vet.
Final Thoughts
Trazodone can be a lifesaver for anxious or reactive dogs, especially in short-term stressful situations. While the 100mg tablet is commonly prescribed, the correct dosage depends on your dog’s weight and health. Always consult your veterinarian, and keep a printable dosage chart handy for peace of mind.
🔗 Download the free Trazodone Dosage Chart PDF now and keep your pup safe and calm.

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.