Is your dog dealing with anxiety, stress, or trouble sleeping? If so, your vet may have mentioned trazodone, a commonly prescribed medication for managing behavioral issues in pets. While it’s widely used in humans, trazodone has gained popularity among veterinarians as a safe and effective option for dogs—especially in higher doses like 100mg.
In this article, we’ll dive into everything you need to know about 100mg trazodone for dogs: what it is, how it works, when it’s prescribed, potential side effects, and key precautions every pet owner should consider.
What Is Trazodone?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) originally developed to treat depression, anxiety, and insomnia in humans. In veterinary medicine, it’s primarily used as an off-label medication to help dogs manage:
- Separation anxiety
- Noise phobias (like fireworks or thunderstorms)
- Travel anxiety
- Veterinary visit stress
- Post-surgical confinement
It works by increasing serotonin levels in the brain, promoting a calming effect without causing significant sedation—making it especially helpful for dogs needing to stay alert but relaxed.
Is 100mg Trazodone Safe for Dogs?
Yes, in most cases—but dosage matters.
Trazodone is generally considered safe and well-tolerated in dogs when prescribed by a veterinarian. The appropriate dose depends on your dog’s:
- Weight
- Age
- Breed
- Overall health
- Other medications being taken
100mg is a common starting or adjusted dose for medium to large dogs, but it’s crucial that this amount is prescribed and monitored by a vet. Giving the wrong dose can lead to adverse effects or reduced effectiveness.
Important: Never give your dog trazodone without veterinary guidance—even if it’s prescribed for another dog.
When Is 100mg Trazodone Prescribed?
Veterinarians may prescribe a 100mg dose in situations like:
- Post-surgical recovery (to keep dogs calm and prevent them from damaging stitches or injuries)
- High-anxiety events (such as fireworks or travel)
- Chronic behavioral issues requiring ongoing treatment
For some dogs, this dose is part of a short-term plan, while others may take it daily or as needed depending on their behavior and response to the medication.
How to Administer Trazodone to Your Dog
Follow your vet’s instructions carefully.
Trazodone is typically given in pill form, either on its own or hidden in food/treats. Some tips for administration:
- Give with food to reduce stomach upset.
- Use pill pockets or peanut butter for easy delivery.
- Avoid crushing the tablet unless advised by your vet.
Onset of action: Trazodone usually starts working within 30 to 90 minutes and can last up to 8–12 hours depending on the dog and dosage.
Potential Side Effects of Trazodone in Dogs
While trazodone is generally well-tolerated, some dogs may experience side effects, especially when starting or increasing the dose.
Common side effects include:
- Lethargy or drowsiness
- Gastrointestinal upset (vomiting, diarrhea)
- Panting or restlessness
- Ataxia (unsteady walking)
- Increased appetite
Rare but serious side effects:
- Aggression or hyperexcitability
- Collapse or fainting
- Serotonin syndrome (if combined with other serotonergic drugs)
If your dog shows any signs of an adverse reaction, contact your vet immediately.
Can Trazodone Be Combined With Other Medications?
Trazodone is often used alongside other medications such as:
- Gabapentin (for pain or anxiety)
- Fluoxetine or Clomipramine (antidepressants)
- NSAIDs (for pain and inflammation)
However, combining drugs can increase the risk of side effects, particularly serotonin syndrome, a potentially serious condition caused by excess serotonin. That’s why it’s essential to inform your vet of all medications and supplements your dog is taking.
What If You Miss a Dose?
If you forget to give your dog a dose of trazodone:
- Give it as soon as you remember, unless it’s close to the time of the next dose.
- Do not double up to make up for a missed dose.
- Stick to the regular schedule as prescribed.
Consistency is key for dogs on long-term trazodone regimens.
Frequently Asked Questions
Can I give my dog human trazodone?
Yes, but only with veterinary approval. Human trazodone is often prescribed for dogs, but dosing and safety must be assessed by a professional.
How long can a dog stay on trazodone?
Some dogs take trazodone long-term, while others use it situationally. Your vet will monitor your pet’s progress and adjust as needed.
Will trazodone make my dog sleepy?
Mild drowsiness is common, but trazodone is designed to calm—not sedate—most dogs. If your pet becomes overly sleepy, talk to your vet about dosage adjustments.
Final Thoughts: Should You Use 100mg Trazodone for Your Dog?
Trazodone can be a game-changer for dogs struggling with anxiety, stress, or post-surgical confinement. At the 100mg dose, it’s a popular and effective option for medium to large dogs—but like any medication, it must be used responsibly under veterinary guidance.
If your dog suffers from anxiety or has a big event coming up, ask your vet whether trazodone is right for them. A calmer, happier pup might be just a dose away.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.