Introduction
Trazodone is a widely used medication primarily prescribed to treat depression and insomnia. It is an atypical antidepressant that works by balancing serotonin levels in the brain, helping to improve mood and sleep quality. However, understanding the correct trazodone dosage is crucial to maximizing its benefits while minimizing potential side effects.
In this guide, we’ll cover everything you need to know about trazodone dosage, including recommended dosages for different conditions, how to take it safely, potential side effects, and tips for optimizing its effectiveness.
Recommended Trazodone Dosage by Condition
1. Trazodone Dosage for Depression
Trazodone is FDA-approved for the treatment of major depressive disorder (MDD). The dosage may vary depending on the severity of the condition and the patient’s response to the medication.
- Initial dose: 150 mg per day, divided into multiple doses
- Maintenance dose: 200–400 mg per day, divided into multiple doses
- Maximum dose: 600 mg per day for hospitalized patients
Note: It’s recommended to start with a lower dose and gradually increase it under a doctor’s supervision to minimize side effects.
2. Trazodone Dosage for Insomnia
Trazodone is commonly prescribed off-label to treat insomnia, as it has sedative properties.
- Low dose range: 25–50 mg before bedtime
- Moderate dose range: 50–100 mg before bedtime
- Maximum dose: Up to 200 mg before bedtime in severe cases
Since trazodone has a sedating effect, it is usually taken 30 minutes to an hour before sleep to improve sleep onset and quality.
3. Trazodone Dosage for Anxiety Disorders
Trazodone is sometimes used off-label to help with generalized anxiety disorder (GAD) and panic disorder.
- Initial dose: 50 mg per day
- Maintenance dose: 75–150 mg per day
- Maximum dose: 300 mg per day (divided doses)
It is usually taken with food to improve absorption and reduce stomach discomfort.
How to Take Trazodone Safely
To ensure safe and effective use, follow these guidelines:
- Take trazodone with food to enhance absorption and reduce nausea.
- Avoid alcohol and sedatives, as they can increase drowsiness.
- Do not abruptly stop taking trazodone, as withdrawal symptoms like irritability and dizziness may occur.
- Follow your doctor’s prescription and do not exceed the recommended dosage.
- Monitor for side effects and report any concerns to your healthcare provider.
Potential Side Effects of Trazodone
While trazodone is generally well-tolerated, it may cause some side effects. Common and serious side effects include:
Common Side Effects:
- Drowsiness
- Dry mouth
- Dizziness
- Headache
- Blurred vision
Serious Side Effects:
- Priapism (prolonged erection in men) – Seek immediate medical attention.
- Serotonin syndrome (rare but serious) – Symptoms include confusion, hallucinations, and rapid heart rate.
- Low blood pressure – May cause fainting or dizziness, especially when standing up.
If you experience any severe side effects, contact a healthcare professional immediately.
Tips for Optimizing Trazodone’s Effectiveness
Maximize the benefits of trazodone by following these simple tips:
- Consistency is key – Take it at the same time every day.
- Start low and go slow – Increase dosage gradually under medical supervision.
- Maintain good sleep hygiene – Avoid screens, caffeine, and heavy meals before bedtime.
- Stay hydrated and eat a balanced diet to reduce side effects like dry mouth and dizziness.
Conclusion
Trazodone is an effective medication for treating depression, insomnia, and anxiety, but correct dosage and adherence to medical advice are crucial for safety and effectiveness. If you’re considering trazodone, consult your doctor to determine the appropriate dosage based on your health condition and individual needs.
By following proper guidelines, being aware of potential side effects, and taking the medication responsibly, you can experience the full benefits of trazodone while minimizing risks.
If you have any concerns or need further clarification, consult your healthcare provider today!

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.