Trazodone is a widely prescribed medication often used to treat depression, anxiety, and insomnia. If you’ve been prescribed 100mg of trazodone, it’s natural to wonder about the potential side effects. While trazodone can be highly effective, it’s important to be aware of how your body might respond to it.
In this article, we’ll dive into the common, less common, and serious side effects of taking 100mg trazodone. Whether you’re a new user or just researching, this guide will give you the clarity you need.
What Is Trazodone?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) used primarily as an antidepressant. It’s also frequently prescribed off-label for sleep disorders due to its sedative effects.
- Brand names: Desyrel, Oleptro
- Typical dosage: Ranges from 50mg to 300mg per day
- 100mg dosage: Common for both sleep and depression treatment, depending on patient needs
Common Side Effects of 100mg Trazodone
Most people tolerate trazodone well, especially at lower doses like 100mg. However, some common side effects may still occur as your body adjusts to the medication.
1. Drowsiness and Fatigue
Trazodone is well-known for its sedative properties.
- Often used as a sleep aid
- Best taken before bedtime
- May cause daytime sleepiness in some users
2. Dizziness or Lightheadedness
This can happen particularly when:
- Standing up quickly
- Beginning treatment
- Increasing dosage
Tip: Avoid driving or operating heavy machinery until you know how trazodone affects you.
3. Dry Mouth
Many users report a dry, cotton-mouth feeling. This can usually be managed by:
- Drinking more water
- Chewing sugar-free gum
- Using oral moisturizing sprays
4. Nausea or Upset Stomach
Some individuals may experience:
- Mild nausea
- Indigestion
- Decreased appetite
Taking trazodone with food can help minimize these effects.
Less Common but Notable Side Effects
While less frequent, these side effects can still occur:
- Headaches
- Blurred vision
- Constipation
- Weight changes
- Mood swings or irritability
If these symptoms persist or worsen, speak with your healthcare provider.
Serious Side Effects to Watch Out For
Though rare, some side effects of trazodone at 100mg can be serious. Seek immediate medical attention if you notice:
1. Irregular Heartbeat
Trazodone can affect heart rhythm in sensitive individuals.
- Symptoms: palpitations, fluttering chest, fainting
2. Priapism (Prolonged Erection)
This is a medical emergency. Though rare, trazodone has been linked to painful, prolonged erections, especially in male users.
3. Serotonin Syndrome
A potentially life-threatening condition when trazodone is taken with other serotonin-affecting drugs (e.g., SSRIs, MAOIs).
Symptoms include:
- Agitation
- High fever
- Rapid heartbeat
- Tremors or muscle stiffness
4. Suicidal Thoughts or Behavior
As with many antidepressants, trazodone may increase suicidal thoughts in young adults and teens, particularly during the first few weeks of treatment.
Always communicate any unusual thoughts or behaviors to your doctor.
How Long Do Side Effects Last?
- Mild side effects often resolve within a few days to a few weeks
- Serious side effects require immediate attention
- Adjusting the dosage may help improve tolerance
Tips to Minimize Side Effects
Here are some ways to reduce or manage side effects of 100mg trazodone:
- Take at night to reduce drowsiness during the day
- Start with a lower dose and increase gradually
- Avoid alcohol and other sedatives
- Stay hydrated and maintain a healthy diet
- Keep open communication with your prescribing doctor
Who Should Avoid Trazodone?
Trazodone may not be suitable for everyone. Consult your doctor if you have:
- Heart conditions
- A history of bipolar disorder
- Liver or kidney problems
- History of substance abuse
- Are pregnant or breastfeeding
When to Contact a Doctor
You should contact your healthcare provider if:
- Side effects are persistent or bothersome
- You experience chest pain, severe dizziness, or unusual thoughts
- You want to adjust your dose or stop taking the medication
Never stop trazodone suddenly without professional guidance. It may lead to withdrawal symptoms like anxiety, agitation, or sleep disturbances.
Final Thoughts
Taking 100mg of trazodone can be a helpful treatment for depression, anxiety, or sleep issues. However, like any medication, it comes with potential side effects. Understanding what’s normal and what’s not can help you feel more confident in your treatment journey.
If you’re starting trazodone or already taking it, keep track of how you feel, and don’t hesitate to talk to your doctor about any concerns. Being proactive can make all the difference in managing your health effectively.

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.