Trazodone is a commonly prescribed antidepressant, often used to treat major depressive disorder, anxiety, and insomnia. While effective for many, stopping trazodone—especially at higher doses like 150mg—can come with a variety of withdrawal symptoms. If you’re considering tapering off trazodone or have already started the process, it’s essential to understand what withdrawal may look like and how to navigate it safely.
In this article, we’ll explore what happens when you stop taking 150mg of trazodone, the potential withdrawal symptoms, how long they last, and tips for easing the process.
What is Trazodone?
Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI). It works by increasing serotonin levels in the brain, which helps regulate mood, sleep, and anxiety.
While not considered physically addictive, trazodone can lead to withdrawal symptoms when stopped suddenly, especially after long-term use or high doses.
Can You Experience Withdrawal from 150mg of Trazodone?
Yes, withdrawal is possible at 150mg, particularly if the medication is stopped abruptly or without medical supervision. While trazodone withdrawal is generally not life-threatening, it can be uncomfortable and distressing.
Why Withdrawal Happens
When you take trazodone regularly, your brain adapts to the increased serotonin activity. Suddenly stopping the drug disrupts this balance, leading to physical and psychological symptoms as your body readjusts.
Common 150mg Trazodone Withdrawal Symptoms
The intensity and duration of symptoms vary from person to person, but some of the most commonly reported include:
- Insomnia or disturbed sleep
- Anxiety or agitation
- Dizziness or lightheadedness
- Fatigue or lethargy
- Mood swings or irritability
- Nausea or digestive issues
- Flu-like symptoms (headache, sweating, chills)
Important: Symptoms typically begin within a few days after the last dose and may last from several days to a few weeks, depending on factors like dosage, duration of use, and individual response.
How Long Does Trazodone Withdrawal Last?
The withdrawal timeline can differ, but here’s a general overview:
Week 1:
- Withdrawal symptoms usually start within 24–72 hours after stopping.
- Anxiety, insomnia, and dizziness are common early symptoms.
Week 2:
- Symptoms may peak in intensity, especially if not tapered gradually.
- Mood-related symptoms like irritability or depression may surface.
Week 3 and Beyond:
- Most physical symptoms improve, but mental health symptoms may linger.
- Ongoing sleep disturbances can persist for some.
For many, symptoms resolve within 2–4 weeks, but those with long-term use may experience longer-lasting effects.
Safe Tapering Off Trazodone: Why Gradual Reduction Matters
Going “cold turkey” with trazodone—especially from a 150mg dose—is not recommended. A gradual tapering process helps your body adjust and minimizes withdrawal symptoms.
Tips for Tapering Safely:
- Consult your doctor before making any changes.
- Reduce your dose slowly (e.g., 25–50mg every 1–2 weeks).
- Track your symptoms and communicate with your provider.
- If severe symptoms arise, pause or slow the taper.
Pro Tip: Some people may benefit from switching to a liquid form of trazodone for more precise tapering.
Managing Trazodone Withdrawal Symptoms
Withdrawal isn’t just about stopping the medication—it’s about supporting your body and mind through the transition. Here are a few ways to ease the process:
Sleep Support
- Establish a calming bedtime routine
- Consider melatonin or herbal sleep aids (with medical guidance)
- Avoid caffeine and electronics at night
Mood & Anxiety Management
- Practice mindfulness or meditation
- Stay active with light exercise like walking or yoga
- Join a support group or seek therapy
Diet & Hydration
- Eat nutrient-rich foods to support brain function
- Stay hydrated to reduce fatigue and brain fog
When to Seek Help
If withdrawal symptoms become overwhelming or interfere with daily life, seek medical advice immediately. This is especially important if you experience:
- Severe mood swings or suicidal thoughts
- Persistent insomnia
- Inability to function normally
A healthcare provider can help adjust your taper plan or offer temporary medications for relief.
Final Thoughts: You’re Not Alone
Withdrawing from 150mg of trazodone can be challenging, but it’s manageable with the right plan and support. Remember, everyone’s journey is unique—what matters is finding a safe, sustainable path forward.
Whether you’re tapering off for the first time or struggling with symptoms, don’t hesitate to reach out for help. Your health and well-being come first.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.