Introduction
Trazodone is a commonly prescribed medication for depression, anxiety, and insomnia. While it can be effective in managing these conditions, it is essential to understand the potential side effects associated with its use. Whether you’re starting trazodone or considering it as a treatment option, knowing how it may affect your body can help you make an informed decision.
In this article, we will explore the common, serious, and long-term side effects of trazodone, along with tips on how to manage them effectively.
Common Side Effects of Trazodone
Most people taking trazodone experience mild to moderate side effects, which often improve as the body adjusts to the medication. These include:
1. Drowsiness and Fatigue
Trazodone has sedative properties, which is why it is often prescribed for insomnia. However, excessive drowsiness during the day can be problematic, especially for those who need to stay alert for work or daily activities.
2. Dizziness and Lightheadedness
Some individuals may experience dizziness or lightheadedness, particularly when standing up quickly. This occurs due to a drop in blood pressure, a condition known as orthostatic hypotension.
3. Dry Mouth
A dry or cottonmouth feeling is another common side effect. Staying hydrated and chewing sugar-free gum can help alleviate this discomfort.
4. Nausea and Digestive Issues
Some users report nausea, vomiting, constipation, or diarrhea when starting trazodone. Taking the medication with food may reduce gastrointestinal discomfort.
5. Blurred Vision
Blurred vision or other visual disturbances can occur, making activities like reading or driving more challenging. If this persists, consult a healthcare provider.
Serious Side Effects of Trazodone
While rare, trazodone can cause serious side effects that require immediate medical attention.
1. Serotonin Syndrome
When taken in combination with other serotonin-boosting medications, trazodone can lead to serotonin syndrome—a potentially life-threatening condition. Symptoms include:
- Agitation or confusion
- Rapid heart rate
- Excessive sweating
- Tremors or muscle stiffness
- High fever
2. Priapism (Prolonged Erection)
Trazodone has been linked to priapism, a rare but serious condition involving a prolonged and painful erection. If left untreated, it can cause permanent damage. Seek emergency medical help if this occurs.
3. Irregular Heartbeat (Arrhythmia)
Some individuals may experience heart palpitations or irregular heart rhythms, which could indicate a serious cardiac issue. Those with pre-existing heart conditions should be particularly cautious.
4. Suicidal Thoughts
As with many antidepressants, trazodone carries a black box warning for increased risk of suicidal thoughts, particularly in young adults. Close monitoring by a healthcare professional is essential, especially in the early stages of treatment.
Long-Term Side Effects and Considerations
Trazodone is generally safe for long-term use when taken as prescribed, but some individuals may experience persistent or worsening symptoms over time.
1. Dependency and Withdrawal
Although trazodone is not considered addictive, sudden discontinuation can lead to withdrawal symptoms such as:
- Insomnia
- Irritability
- Dizziness
- Nausea
- Mood swings
To minimize withdrawal effects, it’s best to taper the dosage under a doctor’s supervision.
2. Weight Changes
Some people experience weight gain or loss while taking trazodone. This can result from changes in appetite, metabolism, or energy levels.
3. Cognitive Impairment
Long-term use of trazodone may contribute to memory issues or brain fog, particularly in older adults. If cognitive decline is noticeable, consulting a doctor is advisable.
How to Manage Trazodone Side Effects
If you experience side effects while taking trazodone, there are ways to manage them effectively:
- Start with a low dose: This allows your body to adjust gradually.
- Take it at night: Since trazodone can cause drowsiness, taking it before bed minimizes daytime fatigue.
- Stay hydrated: This helps combat dry mouth and dizziness.
- Monitor your symptoms: Keep a journal to track any adverse reactions and discuss them with your doctor.
- Avoid alcohol and sedatives: These substances can intensify drowsiness and other side effects.
When to Seek Medical Help
Contact your healthcare provider if you experience persistent, severe, or unusual side effects. Seek emergency help for symptoms such as:
- Difficulty breathing
- Severe dizziness or fainting
- Chest pain
- Seizures
Conclusion
Trazodone can be an effective medication for depression, anxiety, and sleep disorders, but like all medications, it comes with potential side effects. Understanding the risks and how to manage them can help you use trazodone safely and effectively.
If you have concerns about trazodone’s side effects, consult your doctor to determine the best approach for your health and well-being.

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.