Introduction
Dogs, like humans, can suffer from anxiety, stress, and sleep disorders. Whether it’s separation anxiety, fear of thunderstorms, or post-surgical restlessness, pet owners often seek safe solutions to help their furry friends. One medication that veterinarians frequently prescribe is trazodone. But how do you determine the right trazodone dosage for dogs? In this article, we’ll explore trazodone’s uses, benefits, potential side effects, and correct dosage to ensure your pup gets the best care possible.
What Is Trazodone?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI), primarily used as an antidepressant in humans. However, it has gained popularity in veterinary medicine due to its calming effects and ability to treat anxiety and behavioral issues in dogs.
Common Uses of Trazodone in Dogs
- Anxiety relief (e.g., separation anxiety, noise phobias)
- Pre- and post-surgical sedation
- Fear-based aggression management
- Travel-related stress reduction
- Supplemental therapy for behavioral disorders
Determining the Right Trazodone Dosage for Dogs
Factors Influencing Dosage
The appropriate trazodone dosage for dogs depends on various factors, including:
- Dog’s weight
- Age and overall health
- Severity of anxiety or behavioral issues
- Other medications being taken
Typical Dosage Guidelines
Veterinarians typically prescribe trazodone at 2.5 to 15 mg per kilogram (mg/kg) of body weight, given every 8 to 24 hours as needed. However, the dosage should always be determined by a veterinarian.
Dosage Chart by Weight (General Guidelines)
Dog’s Weight (lbs) | Low Dose (mg) | High Dose (mg) |
---|---|---|
10 lbs (4.5 kg) | 11 mg | 68 mg |
20 lbs (9 kg) | 23 mg | 135 mg |
50 lbs (22.7 kg) | 57 mg | 340 mg |
80 lbs (36.3 kg) | 91 mg | 545 mg |
100 lbs (45.4 kg) | 114 mg | 680 mg |
Note: Always start with the lowest effective dose and increase only under veterinary supervision.
How to Administer Trazodone to Dogs
- Give with food to reduce the risk of gastrointestinal upset.
- Administer 1-2 hours before a stressful event (e.g., vet visit, thunderstorms, fireworks).
- Monitor your dog’s reaction and report any concerning side effects to your vet.
Potential Side Effects of Trazodone in Dogs
While trazodone is generally safe, some dogs may experience mild to moderate side effects. These can include:
- Lethargy and drowsiness
- Gastrointestinal issues (vomiting, diarrhea)
- Incoordination or weakness
- Increased heart rate
- Agitation or restlessness (rare but possible)
When to Contact Your Veterinarian
Seek immediate veterinary attention if your dog shows signs of severe lethargy, difficulty breathing, seizures, or an abnormal heart rate.
Can Trazodone Be Used with Other Medications?
Trazodone can be safely used alongside other medications, but only under veterinary supervision. Some common drug interactions include:
- Sedatives or tranquilizers (may cause excessive sedation)
- Antidepressants (SSRIs, MAOIs) (risk of serotonin syndrome)
- Pain medications (NSAIDs, opioids)
- Antihistamines (increased drowsiness)
Alternatives to Trazodone for Anxiety in Dogs
If trazodone isn’t suitable for your dog, consider these alternatives:
- Natural supplements (CBD oil, melatonin, L-theanine)
- Behavioral training and conditioning
- Pheromone therapy (Adaptil diffusers, collars)
- Other medications (fluoxetine, gabapentin, clonidine)
Conclusion
Trazodone is a safe and effective medication for managing anxiety and stress-related behaviors in dogs when used appropriately. Determining the correct dosage is crucial to avoid side effects and ensure effectiveness. Always consult your veterinarian before starting trazodone to ensure it’s the best option for your pet.
If you found this guide helpful, share it with fellow pet owners and consult your vet for personalized advice on your dog’s anxiety management!

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.