Introduction
Trazodone is a widely used medication for dogs, primarily prescribed for anxiety, stress, and behavioral issues. If your veterinarian has recommended trazodone for your furry friend, it’s essential to understand the correct dosage per pound to ensure safety and effectiveness. This guide will provide a detailed overview of trazodone dosage for dogs per pound, how it works, potential side effects, and essential considerations before administering the medication.
What is Trazodone?
Trazodone is an antidepressant medication that belongs to the serotonin antagonist and reuptake inhibitor (SARI) class. It is commonly used in humans for depression and sleep disorders but has gained popularity in veterinary medicine for treating canine anxiety and stress-related behaviors.
How Does Trazodone Work?
Trazodone increases serotonin levels in the brain, which helps regulate mood and promote relaxation. Veterinarians often prescribe it for:
- Separation anxiety
- Fear of loud noises (e.g., thunderstorms, fireworks)
- Post-surgical calming
- Travel anxiety
- Aggression or excessive barking due to stress
Recommended Trazodone Dosage for Dogs Per Pound
The typical trazodone dosage for dogs is between 1.7 mg to 9 mg per pound of body weight. However, the exact dose depends on factors such as the dog’s size, age, medical history, and severity of anxiety.
General Dosage Guidelines
Dog’s Weight (lbs) | Low Dose (1.7 mg/lb) | High Dose (9 mg/lb) |
---|---|---|
10 lbs | 17 mg | 90 mg |
20 lbs | 34 mg | 180 mg |
30 lbs | 51 mg | 270 mg |
40 lbs | 68 mg | 360 mg |
50 lbs | 85 mg | 450 mg |
60 lbs | 102 mg | 540 mg |
70 lbs | 119 mg | 630 mg |
80 lbs | 136 mg | 720 mg |
90 lbs | 153 mg | 810 mg |
100 lbs | 170 mg | 900 mg |
Factors Affecting Dosage
Several factors can influence the correct trazodone dosage for your dog:
- Medical history: Dogs with liver or kidney issues may require lower doses.
- Age and metabolism: Older dogs or those with slower metabolisms may need adjustments.
- Other medications: Some drugs can interact with trazodone, affecting its effectiveness.
- Severity of anxiety: Dogs with mild anxiety may need a lower dose, while those with severe stress may require a higher amount.
How to Administer Trazodone to Dogs
Trazodone is typically available in tablet form and should be given orally, with or without food. To maximize its effectiveness, follow these best practices:
- Give the medication as prescribed: Never exceed the recommended dosage without consulting your vet.
- Start with a lower dose: If your dog is new to trazodone, veterinarians often recommend starting at the lower end of the dosage range.
- Allow time for effects: Trazodone takes 30 to 90 minutes to start working and reaches peak effectiveness within 2-3 hours.
- Monitor for side effects: Keep an eye on your dog’s behavior and physical reactions.
Potential Side Effects of Trazodone in Dogs
While trazodone is generally safe, some dogs may experience mild to moderate side effects, including:
- Drowsiness or lethargy
- Gastrointestinal issues (vomiting, diarrhea)
- Panting or restlessness
- Incoordination or stumbling
- Increased heart rate
When to Contact a Veterinarian
Seek immediate veterinary attention if your dog exhibits severe side effects, such as:
- Excessive sedation or unresponsiveness
- Agitation or unusual aggression
- Difficulty breathing
- Seizures
Precautions and Safety Considerations
Before giving trazodone to your dog, consider the following safety tips:
- Avoid sudden discontinuation: Stopping trazodone abruptly can cause withdrawal symptoms.
- Check for drug interactions: If your dog is on other medications (e.g., sedatives, antidepressants), consult your vet for possible interactions.
- Use caution in pregnant or lactating dogs: The safety of trazodone in breeding dogs is not well established.
- Monitor for serotonin syndrome: Although rare, excessive serotonin levels can cause tremors, hyperthermia, and increased heart rate.
Frequently Asked Questions
Can I Give My Dog Trazodone Every Day?
Yes, trazodone can be used daily or on an as-needed basis, depending on your veterinarian’s recommendation.
How Long Does Trazodone Last in Dogs?
Trazodone effects typically last 8-12 hours, though this can vary based on the dog’s metabolism and dosage.
Can I Give My Dog Trazodone and Benadryl Together?
Combining trazodone with other sedatives, like Benadryl, should only be done under veterinary guidance to avoid excessive drowsiness or respiratory depression.
Conclusion
Trazodone is a safe and effective medication for managing anxiety and stress in dogs when used correctly. By understanding the proper trazodone dosage per pound, monitoring for side effects, and consulting with your veterinarian, you can help ensure your dog’s well-being and comfort.
If you have concerns about your dog’s trazodone dosage, always seek professional advice. A veterinarian can provide the best guidance based on your dog’s specific needs.
For more pet health tips and expert veterinary insights, subscribe to our newsletter or visit your local vet clinic today!

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.