Introduction
If your dog experiences anxiety, stress, or difficulty sleeping, your veterinarian may recommend trazodone as a potential solution. Trazodone is a commonly prescribed antidepressant and sedative that helps manage anxiety-related behaviors in dogs. But what is the right trazodone dose for dogs, and how can you ensure its safe use?
In this guide, we’ll cover everything you need to know about trazodone for dogs, including its dosage, benefits, side effects, and precautions.
What Is Trazodone?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) primarily used in humans to treat depression, insomnia, and anxiety disorders. In veterinary medicine, trazodone is prescribed off-label to manage anxiety, phobias, and post-surgical recovery in dogs.
Trazodone Uses in Dogs
1. Anxiety Management
Dogs suffering from separation anxiety, noise phobias, or general stress may benefit from trazodone. It helps by promoting a calming effect without excessive sedation.
2. Post-Surgical Recovery
After surgery, some dogs struggle with restlessness and agitation. Trazodone helps them stay relaxed during recovery, reducing the risk of injury.
3. Travel and Vet Visits
If your dog experiences stress or panic attacks when traveling or visiting the vet, a prescribed dose of trazodone can make the experience less distressing.
Recommended Trazodone Dosage for Dogs
The correct trazodone dose depends on factors like your dog’s weight, health condition, and veterinary recommendation. Generally, the dosage ranges from 2.5 mg to 15 mg per pound (5-30 mg/kg) every 8-24 hours.
General Dosage Guidelines
- Small dogs (under 20 lbs): 25-100 mg per dose
- Medium dogs (20-50 lbs): 100-200 mg per dose
- Large dogs (50-100 lbs): 200-300 mg per dose
- Giant breeds (100+ lbs): 300-400 mg per dose
⚠️ Important: Always follow your veterinarian’s instructions. The dosage may vary based on your dog’s specific condition and tolerance.
How to Administer Trazodone to Dogs
Trazodone is typically available in tablet form and should be given with or without food. To ensure effectiveness:
- Give trazodone at least 60-90 minutes before a stressful event (e.g., thunderstorms, fireworks, travel).
- If prescribed for long-term use, administer it at the same time daily.
- Never exceed the prescribed dosage without veterinary approval.
Potential Side Effects of Trazodone in Dogs
While trazodone is generally safe, some dogs may experience mild to moderate side effects. Common side effects include:
✅ Mild Side Effects:
- Lethargy or drowsiness
- Slight loss of coordination
- Mild stomach upset (vomiting, diarrhea)
⚠️ Serious Side Effects (Rare but Require Vet Attention):
- Excessive sedation or weakness
- Agitation or hyperactivity
- Vomiting, diarrhea, or loss of appetite
- Increased heart rate (tachycardia)
- Serotonin syndrome (when combined with other serotonin-affecting drugs)
If you notice any severe reactions, contact your veterinarian immediately.
Precautions & Drug Interactions
Who Should Avoid Trazodone?
Trazodone may not be suitable for:
- Pregnant or nursing dogs
- Dogs with liver or kidney disease
- Dogs with severe heart conditions
Drug Interactions
Trazodone may interact with certain medications, including:
- MAO inhibitors (e.g., selegiline)
- SSRI antidepressants (e.g., fluoxetine, sertraline)
- Other sedatives or anti-anxiety medications
Always inform your vet about all medications and supplements your dog is taking.
Frequently Asked Questions (FAQs)
1. Can I give my dog trazodone daily?
Yes, but only if prescribed by a vet. Long-term use should be monitored closely.
2. How long does trazodone take to work in dogs?
Trazodone typically starts working within 30 to 90 minutes, with effects lasting 4 to 12 hours.
3. What should I do if my dog overdoses on trazodone?
Signs of overdose include severe lethargy, vomiting, agitation, tremors, or seizures. Seek emergency veterinary care immediately.
4. Can trazodone be used alongside other anxiety medications?
Sometimes, veterinarians prescribe trazodone with other medications like gabapentin or fluoxetine, but this should only be done under professional supervision.
Conclusion
Trazodone is an effective and commonly prescribed medication for dog anxiety, stress, and post-surgical recovery. When used correctly, it can significantly improve your dog’s quality of life. However, proper dosage, administration, and veterinary guidance are crucial to ensuring its safety.
If you think trazodone might be a good fit for your pet, consult your veterinarian to discuss the best approach.

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.