Introduction
If your dog struggles with anxiety, stress, or insomnia, you may have heard about trazodone as a potential solution. Originally developed as an antidepressant for humans, trazodone is commonly prescribed by veterinarians to help dogs manage anxiety, especially in stressful situations like thunderstorms, fireworks, or vet visits. But what is the correct trazodone dosage for dogs by weight in kg? In this guide, we’ll provide a detailed dosage chart, safety guidelines, and key benefits of using trazodone for dogs.
What Is Trazodone?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that helps regulate mood and promote relaxation. While it is primarily used to treat anxiety and behavioral disorders, veterinarians may also prescribe it as a sedative before medical procedures.
Trazodone Dosage Chart for Dogs by Weight (kg)
The correct trazodone dosage depends on your dog’s weight, medical history, and the severity of anxiety. Below is a general guideline based on common veterinary recommendations.
Trazodone Dosage Chart
Dog’s Weight (kg) | Low Dose (mg) | Medium Dose (mg) | High Dose (mg) |
---|---|---|---|
2 – 5 kg | 10 – 25 mg | 25 – 50 mg | 50 – 75 mg |
6 – 10 kg | 25 – 50 mg | 50 – 75 mg | 75 – 100 mg |
11 – 20 kg | 50 – 100 mg | 100 – 150 mg | 150 – 200 mg |
21 – 30 kg | 100 – 150 mg | 150 – 200 mg | 200 – 250 mg |
31 – 40 kg | 150 – 200 mg | 200 – 250 mg | 250 – 300 mg |
41+ kg | 200 – 250 mg | 250 – 300 mg | 300 – 400 mg |
Important: Always consult your veterinarian before administering trazodone to ensure the correct dosage for your pet’s specific needs.
How to Administer Trazodone to Dogs
- Timing: Give trazodone 30 minutes to 2 hours before an anxiety-triggering event for the best effect.
- With or without food: It can be administered with or without food, but giving it with a small meal can reduce stomach discomfort.
- Consistency: If prescribed for long-term anxiety management, give it at the same time daily for optimal results.
Benefits of Trazodone for Dogs
Trazodone offers several benefits for dogs struggling with stress and anxiety:
✅ Reduces anxiety: Helps dogs remain calm in stressful situations. ✅ Promotes better sleep: Useful for dogs with insomnia or restlessness. ✅ Aids post-surgical recovery: Often prescribed after surgery to keep dogs relaxed. ✅ Non-addictive: Considered safe for long-term use under veterinary supervision.
Potential Side Effects of Trazodone
While trazodone is generally well-tolerated, some dogs may experience mild side effects, including:
- Lethargy or drowsiness
- Mild gastrointestinal upset (vomiting or diarrhea)
- Unsteady movements or incoordination
- Increased or decreased appetite
In rare cases, serotonin syndrome (a serious condition) may occur if trazodone is combined with other serotonergic drugs. Signs include:
⚠️ Excessive panting
⚠️ Agitation or restlessness
⚠️ Rapid heart rate
⚠️ Tremors or seizures
If you notice any severe side effects, contact your veterinarian immediately.
When to Avoid Trazodone for Dogs
Trazodone may not be suitable for all dogs. Avoid or use with caution if your dog has:
❌ Liver or kidney disease
❌ Heart conditions
❌ Allergies to trazodone or similar medications
❌ Is pregnant or nursing
❌ Taking other serotonergic medications (e.g., SSRIs, MAOIs)
Always provide your veterinarian with a full list of your dog’s medications before starting trazodone.
Alternatives to Trazodone for Dogs
If trazodone isn’t the right fit for your dog, consider these alternatives:
- Benadryl (diphenhydramine): Mild sedative for short-term anxiety relief.
- CBD oil: A natural option for anxiety and stress management.
- Adaptil pheromone diffusers: Releases calming pheromones to reduce anxiety.
- Prescription medications: Such as fluoxetine (Prozac) or clonidine, based on veterinary advice.
Conclusion
Trazodone is a safe and effective medication for managing anxiety, stress, and post-surgical recovery in dogs. By following the proper dosage chart by weight (kg) and consulting your veterinarian, you can help ensure your dog remains calm and comfortable in stressful situations.
If you think trazodone could benefit your dog, speak with your vet today to determine the right dosage and ensure a safe treatment plan!

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.