Trazodone is commonly prescribed for depression, anxiety, and insomnia. But increasingly, people are curious about its effects when taken in higher doses—specifically, whether 100mg of trazodone can cause a “high.” This article explores that question in depth, covering how trazodone works, the effects of a 100mg dose, and the potential risks of misuse.
If you’re wondering whether 100mg of trazodone can make you feel high, or you’re simply looking to understand more about this medication, read on. This guide provides a clear and comprehensive overview.
What Is Trazodone?
Trazodone is a prescription medication classified as a serotonin antagonist and reuptake inhibitor (SARI). It’s primarily used to treat:
- Major depressive disorder (MDD)
- Anxiety
- Insomnia (off-label use)
- Chronic pain (in some cases)
Trazodone works by increasing serotonin levels in the brain, a chemical that helps regulate mood, sleep, and behavior.
Understanding Trazodone Dosage
Trazodone is available in several dosage forms, including 50mg, 100mg, 150mg, and higher. Doctors usually start patients on a low dose (often 50mg or 100mg) and gradually increase it based on tolerance and response.
Is 100mg a High Dose?
Not really. 100mg of trazodone is considered a moderate dose, especially when used for sleep. In depression treatment, doses can go up to 300mg or more daily. However, how your body reacts to 100mg depends on your tolerance, weight, age, and other medications.
Can 100mg of Trazodone Make You High?
The Short Answer: Unlikely
Trazodone does not produce a euphoric high like opioids, benzodiazepines, or stimulants. While it can cause drowsiness, lightheadedness, or mild sedation, these effects are not typically described as pleasurable or intoxicating.
Why Some People Feel “Weird” on Trazodone
People unfamiliar with sedative medications might interpret trazodone’s side effects as a “high.” These effects may include:
- Drowsiness
- Dizziness
- Disorientation
- Altered mental state
- Slurred speech or slowed thinking
However, these symptoms are more indicative of sedation than recreational intoxication.
Is Trazodone Abused Recreationally?
While not common, there have been rare cases of trazodone misuse, often involving much higher doses than 100mg. Recreational use is risky and not recommended due to the potential for:
- Severe drowsiness or unconsciousness
- Nausea and vomiting
- Cardiac complications (e.g., arrhythmia)
- Serotonin syndrome (especially when combined with other serotonergic drugs)
Trazodone lacks the addictive qualities of typical recreational drugs, making it less likely to be abused.
The Dangers of Taking Trazodone for a High
1. Health Risks
Taking trazodone at higher-than-prescribed doses can result in:
- Low blood pressure
- Fainting
- Heart rhythm disturbances
- Overdose, especially when mixed with alcohol or other depressants
2. Mental Fog and Cognitive Impairment
The sedative effects can significantly impair your ability to:
- Drive
- Work
- Make decisions
3. Potential for Dependence (Psychological)
While not physically addictive, some individuals may begin to rely on trazodone for sleep or mood management outside of a doctor’s supervision.
Signs You Might Be Misusing Trazodone
If you or someone you know is using trazodone in a way not prescribed, look for these signs:
- Taking larger doses than recommended
- Combining trazodone with alcohol or other substances
- Using it for non-medical reasons
- Feeling the need to take it daily for effects other than sleep or mood regulation
Safe Use Guidelines for Trazodone
To stay safe while using trazodone, follow these tips:
- Take only the prescribed dose — do not self-adjust.
- Avoid mixing with alcohol or other central nervous system depressants.
- Take it at night, especially if prescribed for insomnia.
- Inform your doctor about any side effects or changes in how you feel.
- Never take trazodone recreationally — it’s meant for medical treatment.
What to Do If You Feel “High” or Unwell on 100mg of Trazodone
If you feel unusually sedated, confused, or dizzy after taking 100mg of trazodone:
- Sit or lie down to prevent falls.
- Do not drive or operate machinery.
- Call your doctor to report the symptoms.
- Seek emergency care if symptoms include chest pain, breathing issues, or severe confusion.
Conclusion: Should You Worry About a “High” from 100mg Trazodone?
In most cases, 100mg of trazodone will not produce a high in the traditional sense. Instead, it may make you feel sleepy or mildly out of it — which is exactly why it’s often prescribed for insomnia.
However, taking it with the goal of feeling high is dangerous and potentially harmful. Trazodone should be used under a doctor’s supervision, and never for recreational purposes.

Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.