Trazodone is a commonly prescribed medication for depression, anxiety, and insomnia—but when the dosage reaches 500mg, many people have questions. Is it safe? What are the effects? Why would someone be prescribed such a high amount?
Whether you’re taking trazodone yourself, supporting a loved one, or simply curious about the medication, understanding what 500mg of trazodone means is crucial. In this article, we’ll dive into its uses, side effects, safety concerns, and more—in plain, clear language.
What Is Trazodone?
Trazodone is an antidepressant that belongs to the class of serotonin antagonist and reuptake inhibitors (SARIs). Originally developed to treat major depressive disorder (MDD), it’s also widely prescribed off-label for insomnia, anxiety, and PTSD.
How Trazodone Works
Trazodone increases serotonin levels in the brain by blocking serotonin reuptake. This helps improve mood, reduce anxiety, and promote better sleep.
Common dosages include:
- 50mg to 150mg for insomnia
- 150mg to 300mg for depression
- Higher doses (up to 600mg daily) for more severe psychiatric conditions (usually split throughout the day)
Is 500mg of Trazodone a Normal Dose?
A High Dose, But Sometimes Necessary
While 500mg trazodone is on the high end of the dosage spectrum, it can be prescribed in specific cases where lower doses haven’t been effective—especially in treatment-resistant depression.
- The maximum recommended daily dose for depression is usually around 400mg to 600mg, split into multiple doses.
- 500mg daily is not a starting dose; it’s typically reached gradually under medical supervision.
👉 Important: A 500mg dose is generally not used for sleep. For insomnia, lower doses (like 50-100mg) are usually effective.
What Are the Risks of Taking 500mg Trazodone?
Taking a higher dose increases the potential for side effects and drug interactions. Here’s what to watch for:
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Headache
Serious Side Effects (Less Common)
- Irregular heartbeat
- Low blood pressure (hypotension)
- Priapism (a prolonged, painful erection)
- Serotonin syndrome (when combined with other serotonin-boosting drugs)
Call your doctor immediately if you experience severe symptoms or anything that feels unusual.
Who Might Be Prescribed 500mg of Trazodone?
Typically Used for:
- Major depressive disorder unresponsive to lower doses
- Severe anxiety or PTSD
- Individuals with comorbid conditions where insomnia and depression are both present
Special Considerations
500mg doses are generally reserved for:
- Adults, not children or adolescents
- Patients who have built tolerance to lower doses
- Those closely monitored by a healthcare provider
How Should You Take 500mg Trazodone?
Dosage Instructions
- Usually split into two or three doses per day to reduce side effects
- Take with food to improve absorption and reduce stomach upset
- Do not crush or chew extended-release tablets
Missed a Dose?
Take it as soon as you remember—unless it’s close to your next dose. In that case, skip it. Don’t double up.
Can You Overdose on Trazodone?
Yes—overdosing on trazodone is possible, and 500mg can be dangerous if not properly managed.
Signs of Overdose:
- Extreme drowsiness
- Slow or irregular heartbeat
- Breathing difficulties
- Seizures
If you suspect an overdose, call emergency services or Poison Control immediately.
Tips for Taking Trazodone Safely
✅ Follow your doctor’s directions carefully
✅ Avoid alcohol and other sedatives unless approved
✅ Tell your doctor about other medications you’re taking
✅ Don’t stop taking it suddenly—it should be tapered down gradually
Alternatives to High-Dose Trazodone
If 500mg seems excessive or if side effects become problematic, your doctor might consider:
- Other antidepressants (SSRIs, SNRIs, or atypical antidepressants)
- Cognitive-behavioral therapy (CBT)
- Combination treatments (e.g., trazodone + another med at lower doses)
- Lifestyle changes, like improved sleep hygiene and stress management
Final Thoughts: Is 500mg Trazodone Right for You?
Trazodone is a versatile and effective medication, but 500mg is a high dose that comes with increased risk. If you’re prescribed this amount, it likely means your doctor is addressing a serious mental health condition—and they’re tailoring your treatment accordingly.
As always, stay informed and proactive:
- Ask your doctor questions
- Monitor how you feel
- Report any side effects promptly
Your mental health is important—and so is finding the right treatment. If you’re ever unsure about your medication, talk to your provider. It’s the best way to ensure you’re on a path to healing.
Abraham Finley is a health writer passionate about providing clear, reliable information on Trazodone and mental health. He created TrazodoneSUC.com to help readers make informed decisions about their well-being.